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five logo limited time offer — free shipping toyour door 15% off when you buy 2 or more *Limit one use per customer. offer valid only for high vibes 10mg delta 9 thc 20ct gummies. must have at least 2 gummies in cart to qualify for 15% discount. *all preorders with 10mg delta-9 thc gummies will ship out on 4/5/24. Limit to 1 item per household only. Cannot be combined with any other offer. Availability subject to law. Offer expires 4/20/23. Read five's ToS here. Facebook Twitter Instagram YouTube Representations regarding the efficacy and safety of five™ CBD have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, prevent, treat, or cure any disease. Consult your physician prior to use if you are pregnant, nursing or using other medications. This offer is not redeemable for cash or gift cards, nor is it valid toward previous purchases. Offer may not be combined with any other coupons, discounts, offers, or promotions. Void if altered, copied, transferred, auctioned or sold. Offer may not be reproduced, copied, transferred or sold, including on internet coupon or auction sites. This Offer is considered the Intellectual Property of Five Farms LLC and any duplication or copy without the express prior written consent of Five Farms LLC is considered an unlawful use of Five Farm’s Intellectual Property and is subject to prosecution. Other restrictions may apply. Cash Value 1/10¢. CBD Gummies are edible candies that contain cannabidiol (CBD) oil. They come in a rainbow of flavors, colors, shapes, and concentrations of CBD. Gummies offer a discreet and easy way to ingest CBD, and effective marketing campaigns by many manufacturers mean their popularity has soared among long-standing CBD users and nonusers alike. But because most CBD products are not FDA approved, strengths and purity can vary between brands and even within the same brand, meaning that there is no guarantee that you are getting what you think you are getting. Are there any health benefits of CBD gummies? Manufacturers of CBD gummies claim CBD is effective at relieving anxiety, depression, pain, inflammation, and improving sleep. A CBD product (Epidiolex) has been FDA approved to treat epilepsy. However, research into the effectiveness of CBD oil only tested pure CBD oil, not gummies. Even for pure CBD oil, there are very few well-conducted trials backing up its apparent health benefits, although research is expected to ramp up now that laws distinguish between hemp and marijuana. There is no scientific evidence that gummies work, although anecdotally some people report a benefit and there is likely a strong placebo effect (the act of taking something to relieve your condition makes you feel better even if that product contains nothing). Be aware that CBD is quite a bitter substance, and a lot of gummies contain large amounts of added sugar to disguise this taste. Are CBD products legal? Hemp-derived CBD products that contain less than 0.3% tetrahydrocannabinol (THC) are legal on a federal level; however, they may still be illegal in some states. Marijuana-derived CBD products are illegal on the federal level; however, may be legal in some states. Check your state laws on CBD products. Can CBD gummies make you high? CBD gummies have no psychoactive properties, so they will not give you a high. CBD is derived from hemp, which is almost devoid of THC. THC is the chemical in marijuana that gives you a high. By law, hemp must contain no more than 0.3 percent THC to be considered hemp, otherwise, growers are at risk of prosecution under federal law. The main active ingredient in hemp is CBD, and CBD does not have any psychoactive properties. Instead, CBD has been credited with relieving anxiety, inflammation, insomnia, and pain, although “credited” does not mean proven. What is the difference between CBD, cannabis, hemp, marijuana, and THC? There is still a lot of confusion over what exactly is CBD, with many people thinking cannabis, hemp, marijuana, CBD and THC (tetrahydrocannabinol) are the same thing. They are not. Cannabis is a plant, and there are two main types; Cannabis Indica and Cannabis Sativa. While marijuana can be derived from both types, hemp is only derived from the Cannabis Sativa family. This means that even though hemp and marijuana have a few things in common, there are notable differences, with the most crucial being that hemp is almost devoid of THC, which is the chemical in marijuana that gives you a high. In fact, by law, hemp must contain no more than 0.3 percent THC to be considered hemp, otherwise, growers are at risk of prosecution under federal law. The main active ingredient in hemp is CBD, and CBD does not have any psychoactive properties. Instead, CBD has been credited with relieving anxiety, inflammation, insomnia, and pain, although currently there is little scientific proof that CBD works, except for epilepsy. Epidiolex Is a prescription CBD oil that was FDA approved in June 2018 for two rare and severe forms of epilepsy, Lennox-Gastaut syndrome (LGS) and Dravet syndrome. Other trials are underway investigating the benefits of CBD for Parkinson's disease, schizophrenia, diabetes, multiple sclerosis, and anxiety. In addition to the medicinal uses of CBD, hemp is also a great resource for making 100% biodegradable, environmentally friendly products such as biofuel, building materials, clothing, and paper. Chocoholics will adore the relatively newfound idea of CBD chocolate. This product is exactly what it sounds like: chocolate that’s been infused with CBD. However, you may be wondering whether this is actually a useful product, or whether it’s just a marketing gimmick. If you’re a chocolate-lover, read on to learn about CBD chocolate, including how to make it yourself at home. CBD Chocolate Edibles: What Types Are Available? There are lots of types of CBD chocolate available, and manufacturers may produce it in different ways. Typically, CBD chocolates contain the same CBD oil you can find in tincture form. The manufacturer creates it by mixing the CBD tincture, usually containing coconut oil, into melted chocolate before forming it into its desired shape. Part of the joy of CBD chocolates is that they differ from other CBD edibles. Whereas you would chew and swallow a CBD gummy bear, you can allow CBD chocolate to melt beneath the tongue, creating a cross between the sublingual method of a tincture and the oral form of an edible. This makes CBD chocolates a potentially effective and fast-acting option compared to gummies. That being said, depending on the strength of the chocolate bar you may get a slight aftertaste of hemp. Some manufacturers add extra sweeteners, like honey, to get around this issue. CBD Chocolate Effects The effects of a CBD chocolate bar are very similar to any other consumption method. Of course, effects will vary from person to person. Most CBD users say that chocolate edibles help them to feel relaxed and calm, and allow them to unwind from daily stress. Due to the consumption method, CBD chocolate may not take effect as quickly as tinctures or vapes. In some instances, you might be waiting up to two hours or more before you start to feel anything. All in all, the effects – including how long they take to appear and how long they last – will depend on the strength of the CBD and the user’s tolerance. It is always best to begin with a small amount to see how you feel; we recommend starting with tinctures, so it’s easy to adjust the dose, before moving onto something more potent like CBD chocolate. How to Make CBD Chocolate At Home Believe it or not, you can actually make your own CBD-infused chocolate at home. It may be a cheaper way of doing things, and it also allows you to curate this sweet treat to your personal tastes. Furthermore, you get to decide whether to use full-spectrum CBD, CBD isolate, or a broad spectrum formula. The following CBD chocolate recipe uses a full-spectrum CBD tincture. However, feel free to use whatever cannabinoid blend you desire. Ingredients: 1 cup coconut oil 1 cup chocolate morsels ½ cup honey 1 teaspoon vanilla extract CBD oil of your choice You will need to calculate how much CBD oil you need based on your required dosage. It’s best to use a higher strength tincture rather than adding more oil, as this can affect the consistency, texture, and the overall taste of the chocolate. Instructions: Fill a saucepan halfway with water, then place a heatproof bowl into the top; it should fit snugly. Alternatively, use a double boiler if you have one. Over low-medium heat, add the coconut oil into the bowl. When half of the coconut has melted, add the chocolate, and keep stirring to fully integrate the two. Do not allow it to burn. When everything is melted together, remove the pan from the heat and set it aside to cool, but do not let it harden. Stir in the honey, vanilla extract, and CBD oil. Line a baking tin or mold of the desired size, then pour in the chocolate. Shake it slightly and even it out with a spatula so it sits smoothly. Chill in the fridge or freezer until solidified, then cut into the desired number of pieces. Final Thoughts on CBD Chocolate CBD chocolate is a delicious product, and it’s no surprise that it is growing in popularity. There are many different types available, including deluxe chocolate bars, CBD hot chocolate stirrers, and more. If you cannot find your preferred chocolate type online, then it’s even possible to make CBD chocolate at home. There is lots to love about this tasty snack, but it is perhaps not the best product to start with when trying CBD for the first time. Start with something adjustable, such as a Premium Jane tincture, to find out the appropriate daily amount for you. Then, once you’re experienced in CBD and have become accustomed to listening to your body, feel free to snack on a melt-in-the-mouth, chocolatey treat each day. Cannabidiol (CBD) is an oil derived from the cannabis plant. Possible health benefits include reducing inflammation and pain. However, it is not legal in all states, and there may also be some risks. In June 2018, the Food and Drug Administration (FDA)Trusted Source approved the prescription use of Epidiolex, a purified form of CBD oil, for treating two types of epilepsy. Other forms of cannabis are legal in other states. Cannabis contains a wide range of compounds, with varying effects. Some — but not all— are useful as a treatment. Similarly, some forms — but not all — are legal in some states. This article will look at what CBD is, how it might benefit a person’s health, how to use it, any possible risks, and its legal status in the United States. Is CBD legal?The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.3 percent THC federally legal. However, CBD products containing more than 0.3 percent THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled. ADVERTISEMENT What is CBD oil? CBD oil may help manage symptoms of chronic pain. CBD is one of many cannabinoids (compounds) in the cannabis plant. Researchers have been looking at the possible therapeutic uses of CBD. Two of the compounds in marijuana are delta-9 tetrahydrocannabinol (THC) and CBD. These compounds have different effects. Until recently, THC was the best-known compound in cannabis. It is the most active constituent, and it has a psychological effect. It creates a mind-altering “high” when a person smokes it or uses it in cooking. This is because THC breaks down when a person applies heat and introduces it into the body. CBD, in contrast, is not psychoactive. It does not change a person’s state of mind when they use it. However, it may produce significant changes in the body, and it is showing some significant medical benefits. Find out more about the differences between CBD and THC. Where does CBD come from? CBD comes from the cannabis plant. People refer to cannabis plants as either hemp or marijuana, depending on how much THC they contain. The FDA note that hemp plants are legal under the Farm Bill, as long as they contain less than 0.3%Trusted Source THC. Over the years, marijuana farmers have selectively bred their plants to contain high levels of THC and other compounds that suited their interests. However, hemp farmers rarely modify the plant. CBD oil comes from these legal hemp plants. How CBD works All cannabinoids produce effects in the body by interacting with cannabinoid receptors, which form part of the endocannabinoid systemTrusted Source. The body produces two receptors: CB1 receptors are present throughout the body, particularly in the brain. They co-ordinate movement, pain, emotion, mood, thinking, appetite, memories, and other functions. CB2 receptors are more common in the immune system. They affect inflammation and pain. THC attaches to CB1 receptors but CBD stimulatesTrusted Source the receptors so that the body produces its own cannabinoids, known as endocannabinoids. For more information and resources on CBD and CBD products, please visit our dedicated hub. Benefits CBD may benefit a person’s health in various ways. According to a 2018 studyTrusted Source, reasons for taking CBD oil include: chronic pain arthritis or joint pain anxiety and depression sleep disorder migraine cluster and other headaches post-traumatic stress disorder (PTSD) nausea cancer allergies or asthma epilepsy and other seizure disorders multiple sclerosis (MS) lung conditions Parkinson’s disease Alzheimer’s disease There is some evidence to support some of these uses. How does CBD help relieve pain? Learn more here. Natural pain relief and anti-inflammatory properties Conventional drugs can help relieve stiffness and pain, but some people see CBD as a more natural alternative. There is growing evidenceTrusted Source that the non-psychoactive compounds in marijuana, such as CBD, could provide a new treatment for chronic pain. In 2018, mouse studies showed that CBD reduces inflammation by preventing the release of compounds that trigger inflammation in the body. A 2019 study showed that CBD applied to the skin as an ointment significantly reduced inflammatory skin disease and scarring. Quitting smoking and drug withdrawal A 2013 pilot studyTrusted Source found that smokers who used inhalers containing CBD smoked fewer cigarettes than usual and stopped craving nicotine. This suggests that CBD may help people quit smoking. A 2018Trusted Source study found that CBD helped reduce cravings during withdrawal from tobacco because of its relaxing effect. Authors of a 2015 reviewTrusted Source found evidence that specific cannabinoids, such as CBD, may help people with opioid addiction disorders. The researchers noted that CBD reduced some symptoms associated with substance use disorders. These included anxiety, mood-related symptoms, pain, and insomnia. Research continues to support CBD’s use in managing withdrawal symptoms. Epilepsy After years of research into the safety and effectiveness of CBD oil for treating epilepsy, the FDATrusted Source approved the use of Epidiolex, a purified form of CBD, in 2018. They approved it for treating the following in people aged 3 years and over: Lennox-Gastaut syndrome Dravet syndrome These rare forms of epilepsy involve seizures that are difficult to control with other types of medication. ScientistsTrusted Source are beginning to understand how CBD prevents seizures without the sedating side effects of medications used previously. Synthetic drugs are not yet available that target the endocannnabinoid system as CBD does. Learn more here about Epidiolex (cannabidiol). Alzheimer’s disease Numerous studies have looked at the effect of CBD on Alzheimer’s disease. In 2014, a rodent studyTrusted Source showed that CBD might help people retain the ability to recognize familiar faces. People with Alzheimer’s can lose this ability. One 2019 review found that CBD might help slow the onset and progress of Alzheimer’s disease. More research is underway to understand the dosage better. Some scientistsTrusted Source believe a treatment involving both THC and CHD may be more effective. Other neurological symptoms and disorders Research suggests that CBD may also help treat complications linked to epilepsy, such as neurodegeneration, neuronal injury, and psychiatric diseases. A 2012 studyTrusted Source found that CBD may produce effects similar to those of certain antipsychotic drugs and that the compound may provide a safe and effective treatment for people with schizophrenia. However, further research is necessary. Fighting cancer Authors of a 2012Trusted Source review found evidence that CBD may help prevent the spread of some types of cancer. The compound appears to suppress the growth of cancer cells and promote their destruction. The researchers pointed out that CBD has low levels of toxicity. They called for more research into how CBD could support standard cancer treatments. A 2020 review article discusses adding CBD to chemotherapy drugs to improve the immune system’s response to cancer treatment. Other research has been looking at how CBD might help: prevent the growth of cancer cells reduce anxiety improve the action of chemotherapy lessen the side effects of conventional chemotherapy Learn more here about CBD and cancer. Anxiety disorders Doctors have often advised people with chronic anxiety to avoid cannabis, as THC can trigger or amplify feelings of anxiousness and paranoia. CBD, on the other hand, may help reduce anxiety. A 2019 study showed that CBD significantly reduced symptoms in mice with anxiety. Authors of a 2015 reviewTrusted Source had previously suggested that CBD might help reduce anxiety-related behaviors in people with the following conditions: PTSD general anxiety disorder (GAD) panic disorder social anxiety disorder obsessive-compulsive disorder The authors noted that current treatments could have adverse effects, and some people stop using them for this reason. However, there is no evidence to confirm that CBD has significant adverse effects. Type 1 diabetes Type 1 diabetes occurs when the immune system attacks cells in the pancreas, leading to inflammation. In 2016, researchers found evidence that CBD may ease this inflammation and protect against or delay the onset of type 1 diabetes. In a 2018 study, CBD appeared to have neuroprotective effects on rats with diabetes, including helping preserve their memory and reducing nerve inflammation. Acne Acne treatment is another promising use for CBD. The condition is caused, in part, by inflammation and overworked sebaceous glands in the body. A 2014 studyTrusted Source found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect. Applying CBD topically may reduce inflammation in psoriasis and other inflammatory skin diseases, according to research. CBD is becoming a more common ingredient in skin creams and ointments. However, some experts have concerns about the lack of evidence regarding its effectiveness and the lack of regulation. ADVERTISEMENT Legality The legal status of CBD in the U.S. is complex. Hemp and hemp-derived products are legal under the Farm Bill, as long as their THC content is less than 0.3%.Trusted Source However, there is still some confusion over the specifics. People should check the laws in their state and any travel destination. It is worth remembering that the FDATrusted Source have not yet approved any nonprescription products, which means people cannot be sure about what their product contains. Risks and side effects As with most therapies, CBD use may entail some risks. It may interact with supplements and other drugs. Most CBD products do not have FDA approval, which also means they have not undergone thorough tests. It is not possibleTrusted Source to know if a product: is safe and effective for everyone to use has the properties or contents stated on the packaging Anyone who is using CBD – whether as a prescription drug or in other forms — should first speak to a doctor. Possible adverse effectsTrusted Source include: liver damage interactions with other drugs and alcohol changes in alertness, which can make driving dangerous gastrointestinal problems and loss of appetite mood changes, including irritability and irritation a reduction in fertility for males Future research may prove CBD effective in treating various conditions. For now, however, the FDA urge people not to depend on CBD as an alternative to conventional medical care. During pregnancy ExpertsTrusted Source believe that using marijuana during pregnancy may affect the fetal development of neurons. Regular use among teens is associated with issues concerning memory, behavior, and intelligence. The FDA adviseTrusted Source people not to use CBD during pregnancy or while breastfeeding. How to use CBD There are various ways of using CBD oil. These are not the same as using or smoking whole cannabis. If a doctor prescribes CBD for epilepsy, it is important to follow their instructions. Ways of using CBD products include: mixing them into food or drink taking them with a pipette or dropper swallowing capsules massaging a paste into the skin spraying it under the tongue Recommended dosages vary between individuals and depend on factors such as: body weight the concentration of the product the reason for using CBD Click here to learn more about CBD dosage. Summary There is growing interest in CBD as a therapy for various conditions, but only one product currently has FDA approval. Unapproved products are legal in some, but not all, states. As regulation in the U.S. increases, more specific dosages and prescriptions will start to emerge. For now, people should ask a healthcare professional for advice about which product to use and how much to take. They should also research to ensure they are following regional and local laws. The FDATrusted Source provide information about a wide range of issues relating to CBD use. Cannabidiol (CBD) products are rapidly growing in popularity, both for humans and pets. With the use of CBD on the rise, pet parents and veterinarians alike are now wondering whether it could be an alternative option for multiple pet health conditions. Early research is promising, but it’s best to work with a veterinarian who is familiar with CBD products if you are looking to give them a try for your pet. Here, we’ll discuss current CBD research, if it’s safe to use in pets, and whether it could be the right choice for your furry friend. What is CBD? The marijuana plant has two main active ingredients — delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the substance responsible for the “high” people experience when they use marijuana. CBD, on the other hand, does not cause a “high” and studies suggest it has a range of potential health benefits. While restrictions for purchasing CBD products vary from state to state, many people across the U.S. can easily purchase these items both in stores and online. But it’s important to note that the FDA hasn’t yet determined whether or not CBD is safe as a food additive, dietary supplement, or treatment in pets. Although there is one FDA-approved human medication containing CBD, no products have been approved in animals. What kind of research has been done on the effects of CBD in pets? Unfortunately, there isn’t much research available when it comes to using CBD in pets. Currently, recommendations are either based on veterinarians’ professional experiences or taken from very small studies. As the interest and use of CBD in pets continues to grow, the number and size of these studies will go up as well, providing both veterinarians and pet parents more guidance on how to best use these products. Is CBD safe for pets? It’s important to remember that the FDA has not approved any prescription or over-the-counter CBD products for use in animals. This means that the products on the market may not have been tested for safety or effectiveness before being sold. And some companies may promote unsupported medical claims regarding their products that have not been reviewed or approved, either. There are also concerns regarding CBD product quality. For example, the product might contain a different amount of CBD than what’s on the label, or it might have contaminants like THC or pesticides. So if you decide to try CBD for your pet, you may have to do some extra digging to find out exactly how the product you’re choosing is made. If you have any questions, look on the brand’s website or contact the company to ask for their Certificate of Analysis (COA). This public document verifies that the ingredients written on the label are actually in the product. If the company is not able to provide you with the most up-to-date COA, it is not a good idea to purchase a product from that company. What are the risks of treating my pet with CBD? The side effects of using CBD in animals are very similar to those experienced by humans. The most common issues include changes to appetite, fatigue, and diarrhea. Typically, the higher the CBD dose you give to your pet, the more likely they will have side effects. In most cases, it is not necessary to treat these reactions, as they are generally pretty mild or get better with time. If these side effects don’t get any better or become more severe, you should contact your pet’s veterinarian and keep a close eye on your pet to make sure they don’t hurt themselves. Can CBD cause my pet to get high? As mentioned earlier, CBD does not cause a “high” or euphoric feeling. Some people, however, do say it seems their pets are a little out of sorts when they take CBD. If your pet looks like they could be “high” after their dose, there is a reason why this might be happening. Before purchasing any CBD product, carefully read the label for specific information about its contents. If the product is described as “full spectrum,” this means the product may have up to 0.3% THC in the product — the legal limit according to the Agriculture Improvement Act of 2018. This seemingly small amount could be enough to cause this side effect in your pet, especially if they are extra sensitive to it. What forms of CBD are available for pets? If your veterinarian recommends CBD for your pet, there are a range of CBD pet products available, including oils, treats, topical products (lotions, gels, creams), and more. It is often given by mouth or under the tongue. Bottled oils with droppers may be preferable when you first start giving CBD to your pet as it is easier to increase the dose slowly rather than being limited to a fixed amount in a tablet, capsule, or treat. Are human CBD products safe for pets, or do I need CBD products specifically intended for pets? Products meant for humans have the same CBD that would be found in products designed for pets. So, human CBD might be OK to give to your pet, but you’ll want to follow any recommendations from your vet. If the product is not made specifically for pets, it is important to read the label to double-check for ingredients that could be toxic to pets like chocolate, certain essential oils, and artificial sweeteners. Besides being made without these harmful ingredients, pet-specific oral CBD products are usually also flavored with your furry friend in mind — chicken and fish chews, for instance. Be aware that some CBD products have a grassy taste that can make it more difficult to give to your pet. If you find your dog or cat turning their nose up at the product you’ve chosen, try disguising it in a spoonful of peanut butter or your pet’s treat of choice. What CBD dosage should be used for pets? Since there aren’t any FDA-approved products for use in animals, and we don’t have many studies looking at safety and efficacy, further research is needed to determine more exact doses. If your veterinarian recommends CBD, make sure to follow their instructions since dosing may vary depending on why you are using the product. One study looked at the efficacy of CBD oil in helping to alleviate symptoms of osteoarthritis in dogs. Researchers found that 2 mg per kilogram of body weight given twice a day reduced pain without owners reporting any side effects. However, blood test results suggested that there may have been some damage to the liver. This is why it’s important that your vet is involved in making sure that your pet is being monitored appropriately. As with humans who have never taken CBD before, it is important to start your pet on a low dose and raise it slowly. For example, you can start with one-quarter or one-half of the dose on the label to see how your pet reacts to a small amount of CBD. If your pet does not experience symptom relief, your vet may have you give another dose of the same amount in 30 to 60 minutes and continue to see how they respond. Because there isn’t much research available on using CBD in animals, we don’t know the safest maximum dose. It is best to discuss what dose is safe with a veterinarian who has experience using CBD to help your pet’s condition. What pet health problems might CBD help manage? CBD has shown benefit for animals in a range of conditions including, but not limited to, inflammatory problems, seizures, pain relief, and anxiety. Using CBD for pet health problems is based on the body’s endocannabinoid system (ECS). The goal of the ECS is to achieve and maintain balance of all processes in the body. This is thought to be the reason CBD may have so many potential benefits. Keep in mind that every pet’s ECS functions a little bit differently, so CBD may work better for some than others. Pain Once absorbed by an animal’s body, CBD may play a role in lowering inflammation and relieving pain. While experts are still learning exactly how CBD may relieve pain, it’s believed to affect the ECS and other nerves that are involved in creating pain sensations. More specifically, studies have shown that reducing joint inflammation relieves osteoarthritis aches and pains in pets. Anxiety Much like humans, many pets experience anxiety, leading to several troublesome behaviors like urinating inappropriately. CBD is thought to ease nervousness and provide feelings of calm. Experts believe this is because CBD may activate some of the same areas of the brain as serotonin — the hormone that helps us feel happy and relaxed. Seizures CBD has been shown to help with epilepsy in dogs by lowering the frequency of seizures when used in combination with traditional antiseizure medications. Although experts don’t fully understand how CBD treats seizures, it is thought to prevent nerves in the brain from firing too much and lower the number of electrolytes believed to have a role in seizure conditions. A prescription CBD medication called Epidiolex was FDA-approved for two severe seizure conditions called Lennox-Gastaut syndrome and Dravet syndrome in humans in 2018. It is also approved for the treatment of seizures associated with tuberculosis sclerosis complex. However, studies have not been conducted for its use in animals, so it is not recommended to use it in pets. How can I tell if CBD is helping my pet? Because our pets cannot tell us whether they are feeling better, the most reliable way to tell if CBD is working is to watch them and their behaviors. After giving a dose of CBD, keep a close eye on your pet to see if their symptoms seem to be improving or not. Depending on the condition your pet has, symptom relief may happen in as soon as 30 minutes or take up to a few weeks of consistent use. As discussed before, CBD impacts every animal differently. If your vet recommends that you give it a try, you may go through several brands, doses, or forms to find what works for your four-legged companion. But even though finding the right product requires patience, it is worth it to see your pet be their best, happiest self. The bottom line Emerging research suggests that CBD may help with several pet health conditions, including anxiety, chronic pain, and seizures. Although we need more studies to confirm its benefits, many pet parents already use CBD with great results. Because these products haven’t been reviewed or approved by the FDA, you should discuss using CBD with a veterinarian who has experience treating pets with CBD before starting anything new. Together, you’ll come up with a plan on how to safely help your furry friend feel the best they can. CBD stands for cannabidiol. It is one of the many chemical compounds found in hemp and marijuana plants. CBD oil is a supplement that can be added to a variety of different products, such as lip balm, lotion, drinks, and gummies. CBD oil is created by extracting cannabidiol from the flowers and buds of hemp or marijuana plants. The plant cannabis sativa can be classified as either hemp or marijuana, depending on the amount of THC, the chemical that creates a high when consumed, in it. If the particular sativa plant contains less than 0.3 percent THC, it is technically hemp. If the plant has more than 0.3 percent THC, it's classified as marijuana. Hemp is generally used more for CBD extraction, as it contains more CBD and is legal in all 50 states. But how is the CBD extracted from the plant? The process varies by CBD manufacturer. There are many ways to extract CBD from a plant, and they vary in safety and efficiency. It's important to know the difference since how CBD is extracted affects the final product's purity and efficacy. This article will explain the different methods of how CBD oil is made. If you'd like to learn more about the business side of CBD, you can check out our article on how to start a cannabusiness. Carbon Dioxide One of the more popular extraction methods for CBD oil uses carbon dioxide, or CO2. This system takes advantage of how CO2 can function as a gas, solid, and liquid. Closed-loop extractors are most commonly used for CO2 extraction. The process starts with a solid piece of CO2 in a chamber that is then pumped into a second chamber containing the cannabis material. The second chamber is kept at such a pressure that the CO2 stays in a liquid-like state and absorbs the plant's oils and flavors. Then, the CO2-cannabinoid mixture is pumped into a third chamber where the CO2 returns to a gas state, leaving behind the plant's oil and flavors. CO2 extraction is exact and can produce some of the purest cannabinoid extracts when done correctly. However, this is not always the case because of the high cost of equipment and the steep learning curve. When this is done well, CO2 extracted CBD oil is some of the world's purest, but there is ample room for error when done in less-than-optimal conditions. That potential for error is why subcritical CO2 extraction is used mainly by more "boutique" CBD brands. Ethanol Ethanol extraction is another popular extraction process, as it is safe, simple, and effective. In this method, high-grade grain alcohol (ethanol) is used as a solvent to separate CBD and other cannabinoids from the plant itself. Ethanol extraction can be done under warm or cold conditions and is considered extremely time-efficient compared to other CBD extraction processes like CO2 extraction. The CBD oil created with this method is often used for vape pen cartridges and other products. However, this extraction method destroys the cannabis plant waxes, which may have health benefits that some product-makers favor. Liquid Solvents The idea of using a liquid to absorb CBD oil from the cannabis plant doesn't stop with CO2 or ethanol. Naturally liquid substances are also used, including butane, hexane, or isopropyl alcohol. The process works much like the CO2 or ethanol extraction process, as a liquid solvent is run through decarboxylated hemp to remove cannabinoids and terpenes. Liquid solvent extraction is a less expensive and easier way to extract CBD oil and is easy to scale for commercial production, but it has its downsides. Not all solvents can remove all impurities, and the chlorophyll from the plant may remain in the oil, giving it a greenish tinge and a bitter taste. A CBD manufacturer must adjust the process as needed to avoid impurities. As many of the liquid solvents used are highly flammable, this method can be considered more dangerous than others. Oil Infusion Oil infusion is one of the oldest techniques for extracting CBD oil, and many home growers and producers still use this method today. It's one of the most straightforward ways, but it does come with some drawbacks. Before starting oil infusion, the plant material must first be decarboxylated or heated to a specific temperature to activate the compounds. The plant material is added to olive oil or a similar carrier oil and heated at 100 degrees Celsius for a couple of hours. The olive oil can't evaporate out of the CBD oil, so one of the primary downsides is that a lot more oil is used compared to the amount of liquid solvents used in their processes. Secondary Processes As some of the above processes result in impure CBD oil, many manufacturers choose to use one or both of the following secondary processes in order to further purify their product. Winterization Winterization is the secondary process of removing undesirable substances from the oil to result in pure CBD. After the oil is extracted, it is combined with 200 proof alcohol and stirred vigorously until thoroughly mixed. The alcohol thins the crude oil out, as the desirable parts of crude will go into solution with the alcohol while the unwanted parts will coagulate and freeze, allowing them to be filtered out. The mixture is then placed in a deep freezer at below-zero temperatures. Once it has time to freeze overnight, it looks cloudy and is ready for filtration. The filter removes the fats and other such materials. The oil and alcohol mixture is placed in vessels that use paper filters. The actual CBD oil remains with the alcohol solution and passes through the filter while the unwanted frozen parts are caught by it. When the oil is of the desired quality, the mixture can be heated to alcohol's boiling point, which is lower than that of CBD oil, to boil off the alcohol. The alcohol evaporates, and CBD oil is left behind. Distillation For further CBD oil refinement, it is run through a process called short path distillation. This secondary takes advantage of the fact that different CBD oil compounds each have their own boiling point. Short path distillation starts by slowly heating the CBD oil until the unnecessary substances such as terpenoids, flavonoids, and contaminants, begin to boil off. Sometimes a vacuum is also used to separate the vapors with a lower boiling point. The vapors formed travel through a distillation tube until they reach cooling coils, where they condense and drip down into a separate collection container. The process continues until only pure CBD oil is left in the original container. Conclusion Outlined above are the basics of what CBD is and how CBD is made. Following the manufacture of the oil itself also requires manufacturing of delivery mechanisms, which include containers such as vials and bottles, to vape cartridges and other mechanisms. Of course there is a lot more to the manufacturing process such as CBD product packaging. To find more information on domestic commercial and industrial suppliers of custom manufacturing services and equipment on all levels of the supply chain, visit the Thomas Supplier Discovery Platform, where you will find information on over 500,000 commercial and industrial suppliers. HOW WILL CBD MAKE ME FEEL? The impact CBD has on the human body is, given the way we are mostly all made the same inside, similar for many people. However, the dosage you take, the strain of hemp used in the product, how/where the product is grown, extraction and other ingredients included, not to mention the reason you have chosen to take CBD products in the first place, all make for unique experiences. As a very simple explanation, you can think of the core effect of CBD as being similar to that you experience when you take something like Paracetamol (Acetaminophen). When it takes effect you experience the absence of symptoms and a return back to a more ‘normal’ state - more ‘you’. First and foremost, legal, professionally made CBD products in the UK will not get you high. There’s little to no THC present in CBD oil that is sold legally in this country - that’s the psychotropic compound commonly associated with the heady, almost drunk feeling you can get from consuming marijuana. However, that being said, stronger doses of CBD (1,000mg+, far more than would ever normally be consumed) may make you feel ever-so-slightly light headed, briefly, as it works its way into your bloodstream and around the receptors in your body. This is nothing to be concerned about. In fact, this sensation is mostly your own ‘bliss molecule’, the endocannabinoid called Anandamide, being allowed to flow freely as a result of CBD binding to your CB1 and CB2 receptors which then changes the shape, blocking Anandamide’s usual spot, while inhibiting the enzyme which would ordinarily break Anandamide down before it has a chance to get around. If THC is also present, this sits tightly in those receptors so there’s no chance of Anandamide settling in, making for even more of that lovely stuff swimming around your system. But this little ‘rush’ isn’t the case for everyone. In fact, those with acute pain, anxiety, sleep deprivation (to name but a few) often find that all they feel is a sudden sense of equilibrium, perhaps manifested as pain reduction, a wash of soothing calm, or an energy boost. Interestingly, the same goes for many people using medical marijuana for acute distress, even with higher levels of THC present. Many experts have theorised that this feeling of restored balance may come from a regulation of something dubbed an ‘endocannabinoid deficiency’ – an extremely common problem where our bodies have stopped producing and delivering appropriate amounts of Anandamide and a wide variety of other endocannabinoids, resulting in troubles with many cognitive and physiological processes, such as memory, pain, stress response, and appetite. A number of factors are thought to cause endocannabinoid deficiency, such as lack of quality sleep, poor diet and chronic stress. CBD products simply help your body return to centre. HOW CAN I START USING CBD IN THE MOST EFFECTIVE WAY? CBD oral drops The best way to consumer CBD is often a personal choice. The most common way is to start with CBD oil drops, taken under the tongue. Simply place 4-5 drops under your tongue and allow to absorb for 90 seconds before swallowing. It's really important to seek out high a quality product, from a reputable brand where you can be assured that you're getting what's on the label. Ideally a broad spectrum CBD oil, rather than one based on CBD isolate, so that you also get the benefit of the other minor cannabinoids and terpenes present in the cannabis plant (hemp plant). Beware brands trying to pass off Hemp Oil as CBD Oil - they are not the same thing! You can read about the Difference between Hemp Oil and CBD Oil here. KLORIS CBD are one of the most awarded CBD brands, with stringent quality control and are available for next-day delivery from this website, found in leading health spas like Six Senses and Bvlgari and are one of the only CBD oil brands to be recognised under the Medical Cannabis Clinicians Society Criteria For Excellence. HOW CAN CBD AFFECT PEOPLE IN SO MANY DIFFERENT WAYS? Does it seem a little strange to you that some people use CBD to relax while others use it as a pick-me-up? It’s certainly a very special property of CBD products and it comes down to two things: Cannabis is pleiotropic, meaning it has many different effects through many molecular pathways and activates or binds to multiple receptors throughout the body. Cannabis, although not officially labelled as an adaptogen, contains cannabinoids which work in a typically adaptogenic way, adapting their function depending on what the body needs, be that physical, chemical or biological. Cannabis (and adaptogens such as Ginseng and Reishi mushroom), bring the body back into balance, moderating stress response, lowering inflammation and even enhancing mental performance. What’s more, they can possess opposing qualities, such as being stimulating and relaxing at the same time. Whatever your body needs when the adaptogen gets involved. Amazing, huh? DOES CBD REALLY RELIEVE PAIN? CBD for pain relief Cannabinoids on their own are endlessly captivating – there’s so much we have learned already, yet there is still so much more to discover. But one thing we do know is that it’s how these cannabinoids work in synergy with each other (the entourage effect) and with the endocannabinoid system (ECS) that gives the results people are raving about. Really, they’re just a gentle helping hand to encourage your own body to function just as it should. The ECS spans the entire body. It’s considered to be one of the most important and complex networks, alongside the Central Nervous System (CNS) and Immune System. The receptors that make up the ECS have even been found within the CNS and Immune System and are now known to regulate mood, pain, inflammation, appetite, coordination among many, many other functions./p> Because of this, plenty of CBD users have claimed that they find CBD to be extremely effective when it comes to pain relief, when taken internally, as transdermal patches and also when applied topically, as receptors are also found in almost every skin cell throughout all lipid layers. It’s not possible to make any hard claims as to this yet though. IS CBD OIL ADDICTIVE? You may find that once you start taking CBD oil, the change to your body is so wonderful that you’ll not want to be without it! But this isn’t because it’s addictive. It’s just a game-changer. At a molecular level CBD is not in any way addictive and numerous studies have shown this to be the case. In contrast, evidence suggests that CBD may actually help combat existing addiction to substances such as tobacco, alcohol and even opioids. One week-long 2013 study published in the Addictive Behaviours journal found that participants given a CBD inhaler to use every time they felt the need to smoke reduced their number of cigarettes by 40%, while those with the placebo showed no notable difference. Another 2019 study published in the American Journal of Psychiatry observed the effects of treating long-term heroin users with CBD. The 42 subjects were split into three groups, one had 400mg of CBD administered, the second were given 800mg and the third received a placebo. The results showed that those who used CBD experienced significantly less cravings and anxiety induced by the drug cues. CAN I DRINK ALCOHOL WHILE TAKING CBD? Mixing cannabis with alcohol is usually a no-no, as many a teenager will attest to, however, this is not the case when it comes to low THC or THC free CBD products. Where marijuana with booze might leave you feeling very much worse for wear, CBD is actually thought to have the opposite effect by soothing alcohol induced depression and anxiety for a far more relaxed buzz. Better still, the negative side effects of drinking could be somewhat cushioned by including CBD in your tipple. One 2013 study in the journal of Pharmacology Biochemistry and Behaviour, found that CBD reduces the neurodegeneration drinking can cause, while another 2014 study published in the journal of Free Radical Biology and Medicine revealed that CBD protects the liver by inhibiting oxidative stress and increasing the destruction of damaged cells. This, blended with everything else CBD helps your body do, could not only make for a more enjoyable night, but a more bearable morning after too. CAN I TAKE CBD WITH MEDICATION? There is still so much to learn about CBD and this is one area that is crying out for attention - the reason for this being that the potential CBD has for those on medication could possibly be great, or not good at all. Cannabidiol (and cannabis, including THC and all other cannabinoids) has a fantastic safety record as a food supplement, even in high doses. Unlike many pharmaceutical medications there’s no chance of serious harm if you take a little more than you mean to. However, some studies have indicated that CBD has the ability to block a family of enzymes called cytochrome P450, which are responsible for metabolising (and therefore eliminating) 70% to 80% of pharmaceutical drugs in the liver. If enough research is done and safety measures are put into place, this could open up the possibility of patients being able to take much lower doses of their medication when used alongside CBD oil. But it could also indicate build up of pharmaceutical chemicals in your system, which may end being very toxic. Until we know more, it’s best to err on the side of caution. And of course, always consult a medical professional for their expert advice. DOES CBD OIL HAVE ANY NEGATIVE SIDE EFFECTS? A huge and ever-increasing number of studies looking into cannabidiol are now (thankfully and finally!) being published on a yearly basis, and the vast majority of them are pointing towards CBD being a pretty amazing thing in almost all respects. But as this is still a relatively new science (the ECS was only discovered in the 90s after all) and widespread use of concentrated CBD is a recent thing, we are always learning. So far, the World Health Organisation deems CBD as perfectly safe, without risk of dependency or abuse and full of promise for a wide range of medical uses. The only clinical trial showing negative side effects has been through using extremely high doses of Epidiolex, an FDA-approved CBD prescription medication. This looked at daily doses equivalent to 1,360 mg (more than an entire bottle of most CBD products) and even that exhibited mild symptoms such as dry mouth, decreased appetite and gastrointestinal distress. That being said, it is vitally important to be wary of poor quality, unregulated CBD products. When purchasing CBD, always look for organic growing methods and transparent lab reports to ensure you are only ever putting the very best ingredients into your body. HOW LONG WILL I FEEL THE EFFECT OF CBD FOR? You're probably wondering how long does CBD last - this mostly depends on what form of CBD you take (i.e. oil, capsules, vapes, edibles etc). Vaping or using cbd oil drops sublingually (under the tongue) ensures the CBD enters your bloodstream fast, and you’ll start to feel the effects within 5-10 minutes. Capsules and edibles take much longer to get to work (up to 90 minutes) and, due to having to go via your digestive system, will end up having lower bioavailability too (so you need to take much more to have the same effect). But they’re great for a slow, steady, accumulative build up. Once CBD is in your system, however it gets there, it will reach what’s known as ‘elimination half-life’ (the time it takes to reach half the dosage in your body) in 18 to 32 hours. But you won’t feel it as strongly during this whole time as you do when it first gets going (what’s called ‘active life’), even though those lovely cannabinoids will still be subtly working away. HOW CAN I MAKE SURE I GET THE BEST CBD? Knowing which are the best CBD products to try can be a confusing task, but there are a few easy things to check: Make sure the source of the CBD is clearly labelled as hemp, or Cannabis Sativa L. This form of the cannabis plant is naturally low in THC and is the only legal source of CBD for non-medicinal products in the UK and Europe. Ingestible products like CBD oil should ideally be made from broad spectrum CBD extract, meaning that there are other minor compounds present, as naturally found in the hemp plant. There is growing evidence to suggest this more natural form is more beneficial than 'purified' CBD isolate. Ensure that there are current laboratory analysis reports (sometimes called Certificates of Analysis, or COAs) available for your products. These should show the levels of CBD, THC and other cannabinoids. If the certificates don't show the company name and a batch number that matches your product, or are more than a year old, be wary. Organic is always better. Hemp plants are very good at sucking up toxins from the soil. Look for well known third party accreditations, reviews and awards that show the brand is legitimate. 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